Medical Pharmacology (PHARM)

Courses

PHARM 210. Chemical Neuroanatomy. 4 Units.

Organization of the nervous system, especially with respect to chemical identity of elements, for students of pharmacology. Major cell types, methods of study, ultrastructure, synaptic organization of functionally defined systems, localization of chemically defined cells and receptors, and brain development.

Restriction: Graduate students only.

PHARM 241. Advanced Topics in Pharmacology. 2 Units.

Application of pharmacological principles in disease therapy. Advanced pharmacological mechanisms and in-depth study of drug action. Discussion of several major drug classes/therapeutic strategies: molecular mechanisms of action, physiological consequences of administration, and clinical use.

PHARM 241B. Graduate Pharmacology. 6 Units.

Principles of pharmacology and in-depth study of drug action. Pharmacokinetics and pharmacodynamics: absorption, distribution and metabolism, general principles of action and receptor concepts. Discussion of major drug classes: molecular mechanism of action, physiological consequences of administration, and clinical use.

Prerequisite: PHYSIO 206A and PHYSIO 206B and BIOCHEM 210A.

PHARM 251. Experimental Pharmacology. 4 Units.

Introduction to the concepts and techniques used in pharmacological science. Molecular biology, quantitative and biochemical pharmacology, fluorescent probes, behavior, genetics, animal handling, anatomical and receptor binding analysis, methods for ion channel study, the absorption, distribution, metabolism and elimination of drugs.

PHARM 254. Introduction to Pharmacology. 4 Units.

Receptor analysis: bioassay measuring contraction, calcium mobilization, second messenger responses; operant conditioning: whole animal, single neuron; radioligand binding; quantitative autoradiography; immunocytochemistry; in situ hybridization for analysis of mRNA; Western and Northern analysis; transgenic mouse knock in and knock out techniques.

PHARM 255. Chemical Transmission. 4 Units.

Mechanisms underlying chemical signaling processes in the brain and periphery. Molecular biology, signal transduction, transmitter synthesis and inactivation, pharmacology of integrative function and behavior.

PHARM 256. Experimental Design for Pharmacologists. 1 Unit.

Population and sample statistics, hypothesis testing, analysis of variance, nonparametric statistics, experimental design, power, and the use of statistical computer software.

Prerequisite: PHARM 252.

PHARM 257. Ethics in Research. 1 Unit.

Ethical conduct in research including data handling, authorship, conflict of interest, animal rights, handling of misconduct.

Prerequisite: PHARM 299.

Repeatability: May be taken for credit 2 times.

PHARM 270. Applied Pharmacology . 3 Units.

One week (five days, 40 hours) in-residence course offered on the UCI campus. Introduction to pharmacological techniques and current research problems; includes laboratory demonstrations and research seminars.

Restriction: Master's in Pharmacology graduate students only.

PHARM 271. Principles of Pharmacology . 3 Units.

Principles of pharmacology: pharmacodynamics, pharmacokinetics, pharmacogenetics, drug interactions, and toxicity. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 272. Receptors and Drug Targets . 3 Units.

Molecular basis of drug-receptor interaction. Receptor properties including gene and protein structure, signaling mechanisms, trafficking and physiological effects: G-protein linked receptors, ligand-gated ion channels, receptor tyrosine kinases, nuclear receptors, and ligand regulated transcription factors. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 274. Research Techniques in Pharmacology. 3 Units.

Experimental techniques and model systems used in pharmacological research. Receptor analysis, bioassay, molecular biology, in vitro pharmacology, biochemical pharmacology, imaging, electrophysiology, in vivo pharmacology, disease models. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 276. Experimental Design and Data Analysis . 3 Units.

Experimental design, data analysis and interpretation. Population and sample statistics, hypothesis testing, analysis of variance, nonparametric statistics, and power calculations. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 277. Ethics in Scientific Research. 3 Units.

Ethical conduct in research including data handling, authorship, conflict of interest, animal rights, and handling of misconduct. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 278. Concepts in Drug Discovery. 3 Units.

Critical steps involved in discovery and optimization of a new drug. Target selection, relationship of molecular structure to pharmacological activities, screening methods, strategies to identify lead compounds, and preclinical characterization necessary for development of the drug for clinical trials. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 279. Special Topics in Pharmacology. 3 Units.

Topics of current interest in pharmacology; discussion of recent research publications. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 280. Master's Project in Pharmacology. 3 Units.

Capstone research paper on topic of interest in pharmacology. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 281. Neuropharmacology . 3 Units.

Autonomic and central nervous system pharmacology, including major drug classes and therapeutic uses. Mechanisms underlying chemical signaling processes in the brain and peripheral nervous system, including neurotransmitter synthesis, inactivation, and receptor action. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 282. Behavioral Pharmacology. 3 Units.

Pharmacology of integrative function and behavior. Drug treatment of pain. Mechanisms of reward, addiction, and drugs of abuse. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 283. Cardiovascular Pharmacology. 3 Units.

Basic understanding of drugs used in the prevention and treatment of cardiovascular disease. Mechanisms of action, clinical and adverse effects. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 284. Endocrine, Respiratory, and Gastrointestinal Pharmacology . 3 Units.

Basic understanding of drugs used in endocrine, respiratory, and gastrointestinal conditions, including hormone replacement, contraceptives, and drugs for diabetes, asthma, obesity, ulcer, and gastric reflux. Mechanisms of drug action, clinical and adverse effects. Course may be offered online.

Restriction: Master's in Pharmacology graduate students only.

PHARM 298. Seminar. 2 Units.

Presentation and discussion of current problems and methods in teaching and research in pharmacology, toxicology, and therapeutics.

Repeatability: May be repeated for credit unlimited times.

Restriction: Graduate students only.

PHARM 299. Research. 1-12 Units.

Independent research with Pharmacology and Toxicology faculty.

Repeatability: May be repeated for credit unlimited times.

Restriction: Graduate students only.

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