Department of Biomedical Engineering

3120 Natural Sciences II; (949) 824-9196
http://www.eng.uci.edu/dept/bme
Abraham Lee, Department Chair 

Biomedical engineering combines engineering expertise with medical needs for the enhancement of health care. It is a branch of engineering in which knowledge and skills are developed and applied to define and solve problems in biology and medicine. Students choose the biomedical engineering field to be of service to people, for the excitement of working with living systems, and to apply advanced technology to the complex problems of medical care. Biomedical engineers may be called upon to design instruments and devices, to bring together knowledge from many sources to develop new procedures, or to carry out research to acquire knowledge needed to solve new problems.

During the last 20 years, we have witnessed unprecedented advances in engineering, medical care, and the life sciences. The combination of exploding knowledge and technology in biology, medicine, the physical sciences, and engineering, coupled with the changes in the way health care will be delivered in the next century, provide a fertile ground for biomedical engineering. Biomedical engineering, at the confluence of these fields, has played a vital role in this progress. Traditionally, engineers have been concerned with inanimate materials, devices, and systems, while life scientists have investigated biological structure and function. Biomedical engineers integrate these disciplines in a unique way, combining the methodologies of the physical sciences and engineering with the study of biological and medical problems. The collaboration between engineers, physicians, biologists, and physical scientists is an integral part of this endeavor and has produced many important discoveries in the areas of artificial organs, artificial implants, and diagnostic equipment.

The Department offers a B.S. degree in Biomedical Engineering (BME), a four-year engineering curriculum accredited by the Engineering Accreditation Commission of ABET, http://www.abet.org. This program prepares students for a wide variety of careers in Biomedical Engineering in industry, hospitals, and research laboratories or for further education in graduate school.

The Department also offers a B.S. degree in Biomedical Engineering: Premedical (BMEP), a four-year engineering curriculum taken with required premedical courses. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions. It is also suitable for students interested in pursuing graduate work in Biomedical Engineering and other biomedical areas such as physiology, neurosciences, and bioinformatics. The curriculum has less engineering content but more biological sciences and chemistry course work than the Biomedical Engineering major. The undergraduate major in Biomedical Engineering: Premedical is not designed to be accredited, therefore is not accredited by ABET.

Areas of graduate study and research include biophotonics, biomedical nanoscale systems, biomedical computational technologies, and tissue engineering.

 

 

 

Undergraduate Major in Biomedical Engineering

Program Educational Objectives: Graduates of the Biomedical Engineering program will (1) promote continuous improvement in the field of biomedical engineering; (2) communicate effectively the relevant biomedical engineering problem to be solved across the engineering, life science, and medical disciplines; (3) apply critical reasoning as well as quantitative and design skills to identify and solve problems in biomedical engineering; (4) lead and manage biomedical engineering projects in industry, government, or academia that involve multidisciplinary team members. (Program educational objectives are those aspects of engineering that help shape the curriculum; achievement of these objectives is a shared responsibility between the student and UCI.)

Biomedical Engineering students learn engineering and principles of biology, physiology, chemistry, and physics. They may go on to design devices to diagnose and treat disease, engineer tissues to repair wounds, develop cutting-edge genetic treatments, or create computer programs to understand how the human body works.

The curriculum emphasizes education in the fundamentals of engineering sciences that form the common basis of all engineering sub-specialties. Education with this focus is intended to provide students with a solid engineering foundation for a career in which engineering practice may change rapidly. In addition, elements of bioengineering design are incorporated at every level in the curriculum. This is accomplished by integration of laboratory experimentation, computer applications, and exposure to real bioengineering problems throughout the program. Students also work as teams in senior design project courses to solve multidisciplinary problems suggested by industrial and clinical experience.

NOTE: Students may complete only one of the following programs: the major in Biomedical Engineering, the major in Biomedical Engineering: Premedical, or the minor in Biomedical Engineering.

Admissions

High School Students: See School admissions information.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of approved calculus, one year of calculus-based physics with laboratories (mechanics, electricity and magnetism), one year of chemistry (with laboratory), and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

Requirements for the B.S. Degree in Biomedical Engineering

All students must meet the University Requirements.
All students must meet the School Requirements.

Major Requirements

Mathematics and Basic Science Courses:
Students must complete a minimum of 48 units of mathematics and basic sciences including:
Core Courses:
MATH 2A- 2B Single-Variable Calculus
   and Single-Variable Calculus
MATH 2D Multivariable Calculus
MATH 3A Introduction to Linear Algebra
MATH 3D Elementary Differential Equations
MATH 2E Multivariable Calculus
STATS 8 Introduction to Biological Statistics
CHEM 1A- 1B- 1C General Chemistry
   and General Chemistry
   and General Chemistry
CHEM 1LC General Chemistry Laboratory
PHYSICS 7C Classical Physics
PHYSICS 7LC Classical Physics Laboratory
PHYSICS 7D- 7E Classical Physics
   and Classical Physics
PHYSICS 7LD Classical Physics Laboratory
BIO SCI 194S Safety and Ethics for Research
Engineering Topics Courses:
Students must complete a minimum of 28 units of engineering design including:
Core Courses:
Introduction to Biomedical Engineering
Cell and Molecular Engineering
   and Cell and Molecular Engineering
Engineering Analysis/Design: Data Acquisition
   and Engineering Analysis/Design:Data Analysis
   and Engineering Analysis/Design: Computer-Aided Design
Biomechanics I
   and Biomechanics II
   and Biomechanics III
Design of Biomaterials
Quantitative Physiology: Sensory Motor Systems
BME 121 Quantitative Physiology: Organ Transport Systems
Biomedical Signals and Systems
Design of Biomedical Electronics
Biotransport Phenomena
Tissue Engineering
Biomedical Engineering Laboratory
Biomedical Engineering Design
   and Biomedical Engineering Design
   and Biomedical Engineering Design
Engineering Electives:
Students select, with the approval of a faculty advisor a minimum of 12 units of engineering topics needed to satisfy school and major requirements.
(The nominal Biomedical Engineering program will require 186 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary.)
Engineering Professional Topics Course:
ENGR 190W Communications in the Professional World

 

Optional Specialization in Biophotonics

Requires:
BME 135 Photomedicine
BME 136 Engineering Optics for Medical Applications
BME 137 Introduction to Biomedical Imaging
or EECS 180A Engineering Electromagnetics I

These courses will also satisfy the Engineering Electives requirement.

 

Optional Specialization in Micro and Nano Biomedical Engineering

Requires:
BME 149 Biomedical Microdevices I
Select two of the following:
Microfluidics and Lab-on-a-Chip
Microimplants
Microelectromechanical Systems (MEMS)
Advanced BIOMEMS Manufacturing Techniques

These courses will also satisfy the Engineering Electives requirement.

Planning a Program of Study

The sample program of study chart shown is typical for the major in Biomedical Engineering. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study — Biomedical Engineering

Freshman
Fall Winter Spring
MATH 2AMATH 2BMATH 2D
CHEM 1ACHEM 1BCHEM 1C
BME 1PHYSICS 7CCHEM 1LC
General EducationPHYSICS 7LCPHYSICS 7D
 General EducationPHYSICS 7LD
Sophomore
Fall Winter Spring
MATH 3AMATH 3DMATH 2E
PHYSICS 7EBME 50ASTATS 8
BME 60ABME 60BBME 50B
 General EducationBME 60C
Junior
Fall Winter Spring
BME 110ABME 110BBME 110C
BME 120BME 121BME 111
BME 130BME 140BME 150
ENGR 190WGeneral EducationBIO SCI 194S
  General Education
Senior
Fall Winter Spring
BME 160BME 180BBME 170
BME 180AEngineering ElectiveBME 180C
Engineering ElectiveGeneral EducationEngineering Elective
General EducationGeneral EducationGeneral Education

Undergraduate Major in Biomedical Engineering: Premedical

Program Educational Objectives: Graduates of the Biomedical Engineering: Premedical program will: (1) demonstrate a broad knowledge in the field of biomedical engineering; (2) demonstrate critical reasoning as well as quantitative skills to identify, formulate, analyze and solve biomedical problems; (3) qualify to pursue entry into a medical college, or medical research in biomedical engineering, or other professional heal programs. (Program educational objectives are those aspects of engineering that help shape the curriculum; achievement of these objectives is a shared responsibility between the student and UCI.) The major program objective is to prepare students for medical school. The curriculum is designed to meet the requirements for admission to medical schools, but is also suitable for those planning to enter graduate school in biomedical engineering, physiology, biology, neurosciences, or related fields. It has less engineering content and more biological sciences than the accompanying Biomedical Engineering major. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions.

The Biomedical Engineering: Premedical curriculum provides future physicians with a quantitative background in biomechanics, physiology, and biotransport. Such a background is increasingly important because of the heavy utilization of biomedical technology in modern medical practice. The curriculum includes courses in the sciences that satisfy the requirements of most medical schools.

Admissions

High School Students: See School admissions information.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of approved calculus, one year of calculus-based physics with laboratories (mechanics, electricity and magnetism), one year of chemistry (with laboratory), and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

Requirements for the B.S. Degree in Biomedical Engineering: Premedical

All students must meet the University Requirements.
All students must meet the School Requirements.

Major Requirements

Mathematics and Basic Science Courses:
Students must complete a minimum of 48 units of mathematics and basic sciences including:
MATH 2A- 2B Single-Variable Calculus
   and Single-Variable Calculus
MATH 2D Multivariable Calculus
MATH 3A Introduction to Linear Algebra
MATH 3D Elementary Differential Equations
CHEM 1A- 1B- 1C General Chemistry
   and General Chemistry
   and General Chemistry
CHEM 1LC- 1LD General Chemistry Laboratory
   and General Chemistry Laboratory
CHEM 51A- 51B- 51C Organic Chemistry
   and Organic Chemistry
   and Organic Chemistry
CHEM 51LB- 51LC Organic Chemistry Laboratory
   and Organic Chemistry Laboratory
PHYSICS 7C Classical Physics
PHYSICS 7LC Classical Physics Laboratory
PHYSICS 7D- 7E Classical Physics
   and Classical Physics
PHYSICS 7LD Classical Physics Laboratory
Students select, with the approval of a faculty advisor, any additional basic science course needed to satisfy school and major requirements.
Engineering Topics Courses:
Students must complete the following engineering topics including:
BIO SCI 97 Genetics
BIO SCI 98 Biochemistry
BIO SCI 99 Molecular Biology
BIO SCI D103 Cell Biology
or BIO SCI D104 Developmental Biology
BIO SCI 100 Scientific Writing
BIO SCI D111L Developmental and Cell Biology Laboratory
BIO SCI E112L- M114L- M116L Physiology Laboratory
   and Biochemistry Laboratory
   and Molecular Biology Laboratory (select two of these three courses)
BIO SCI 194S Safety and Ethics for Research
BME 1 Introduction to Biomedical Engineering
BME 60A- 60B- 60C Engineering Analysis/Design: Data Acquisition
   and Engineering Analysis/Design:Data Analysis
   and Engineering Analysis/Design: Computer-Aided Design
BME 110A- 110B Biomechanics I
   and Biomechanics II
BME 111 Design of Biomaterials
BME 120 Quantitative Physiology: Sensory Motor Systems
BME 121 Quantitative Physiology: Organ Transport Systems
BME 130 Biomedical Signals and Systems
BME 150 Biotransport Phenomena
BME 160 Tissue Engineering
Students select, with the approval of a faculty advisor, at least three additional engineering topics courses needed to satisfy school and major requirements.

(The nominal Biomedical Engineering: Premedical program will require 193 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary).

Planning a Program of Study

The sample program of study chart shown is typical for the major in Biomedical Engineering: Premedical. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering: Premedical majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study — Biomedical Engineering: Premedical

Freshman
Fall Winter Spring
MATH 2AMATH 2BMATH 2D
CHEM 1ACHEM 1BCHEM 1C
BME 1PHYSICS 7CCHEM 1LC
General EducationPHYSICS 7LCPHYSICS 7D
 General EducationPHYSICS 7LD
Sophomore
Fall Winter Spring
MATH 3AMATH 3DCHEM 51C
CHEM 1LDCHEM 51BCHEM 51LC
CHEM 51ACHEM 51LBBME 60C
PHYSICS 7EBME 60BGeneral Education
BME 60AGeneral EducationGeneral Education
Junior
Fall Winter Spring
BIO SCI 97BIO SCI 98BIO SCI 99
BME 110ABME 110BBME 111
BME 120BME 121BME 150
BME 130Engineering ElectiveGeneral Education
Senior
Fall Winter Spring
BIO SCI 100BIO SCI D103 or D104BIO SCI E112L1
BIO SCI 194SBIO SCI D111LBIO SCI M114L1
BME 160Engineering ElectiveBIO SCI M116L1
General EducationGeneral EducationEngineering Elective
  General Education

1

Select two of BIO SCI E112LBIO SCI M114LBIO SCI M116L.


Minor in Biomedical Engineering

The minor in Biomedical Engineering requires a total of nine courses—two advanced mathematics courses, five core Biomedical Engineering courses, and two Biomedical Engineering electives. Some of these courses may include prerequisites that may or may not be part of a student’s course requirements for their major. Private biomedical industry has indicated a keen interest in engineers that have a more traditional engineering degree (i.e., electrical engineering), but also possess some in-depth knowledge of biomedical systems. Hence, the minor in Biomedical Engineering is designed to provide a student with the introductory skills necessary to perform as an engineer in the biomedical arena.

Admissions. Students interested in the minor in Biomedical Engineering must have a UCI cumulative GPA of 2.5 or higher.

NOTE: Students may not receive both a minor in Biomedical Engineering and a specialization in Biochemical Engineering within the Chemical Engineering major.

Requirements for the Minor in Biomedical Engineering

Mathematics Courses:
MATH 3A Introduction to Linear Algebra
MATH 3D Elementary Differential Equations
Engineering Topics Courses:
BME 1 Introduction to Biomedical Engineering
BME 50A- 50B Cell and Molecular Engineering
   and Cell and Molecular Engineering
BME 120 Quantitative Physiology: Sensory Motor Systems
BME 121 Quantitative Physiology: Organ Transport Systems
Technical Electives:
Students select, with the approval of a faculty advisor, two technical elective courses:
Biomechanics I
Biomechanics II
Biomedical Signals and Systems
Photomedicine
Engineering Optics for Medical Applications
Design of Biomedical Electronics
Tissue Engineering
Individual Study
Transport Phenomena in Living Systems
Polymer Science and Engineering
Microelectromechanical Systems (MEMS)
Optical Electronics

Graduate Study in Biomedical Engineering

The Biomedical Engineering faculty have special interest and expertise in four thrust areas: Biophotonics, Biomedical Nanoscale Systems, Biomedical Computational Technologies, and Tissue Engineering. Biophotonics faculty are interested in photomedicine, laser microscopy, optical coherence tomography, medical imaging, and phototherapy. Biomedical Nanoscale Systems faculty are interested in molecular engineering, polymer chemistry, molecular motors, design and fabrication of microelectromechanical systems (MEMS), integrated microsystems to study intercellular signaling, and single molecule studies of protein dynamics. Biomedical Computation faculty are interested in computational biology, biomedical signal and image processing, bioinformatics, computational methods in protein engineering, and data mining.

The Department offers the M.S. and Ph.D. degrees in Biomedical Engineering.

Required Background

Because of its interdisciplinary nature, biomedical engineering attracts students with a variety of backgrounds. Thus, the requirements for admission are tailored to students who have a bachelor’s degree in an engineering, physical science, or biological science discipline, with a grade point average of 3.20 or higher in their upper-division course work. The minimum course work requirements for admission are six quarters of calculus through linear algebra and ordinary differential equations, three quarters of calculus-based physics, three quarters of chemistry, and two quarters of biology. Students without a physics, chemistry, or engineering undergraduate degree may be required to take additional relevant undergraduate engineering courses during their first year in the program; any such requirements will be specifically determined by the BME Graduate Committee on a case-by-case basis and will be made known to the applicant at the time of acceptance to the program.

The recommended minimum combined verbal and quantitative portion of the GRE is 310, or a minimum combined MCAT score in Verbal Reasoning, Physical Sciences, and Biological Sciences problems of 30. A minimum score of 94 on the Test of English as a Foreign Language (TOEFL iBT) is recommended of all international students whose native language is not English. In addition, all applicants must submit three letters of recommendation.

Exceptionally promising UCI undergraduates may apply for admission through The Henry Samueli School of Engineering’s accelerated M.S. and M.S./Ph.D. program, however, these students must satisfy the course work and letters of recommendation requirements described above.

Core Requirement

Both the M.S. and Ph.D. degrees require the students to complete 42 course units. These units include six core courses, the BME 298 seminar series, two elective courses, and four units of independent research. The core courses cover the basics of cells, tissues, and physiology at the microscopic and macroscopic scale, engineering mathematics, and clinical theory. The core courses are BME 210, BME 220, BME 221, BME 230A, BME 230B, BME 240, and three quarters of BME 298. Core requirements can be waived for students entering the Ph.D. program with an M.S. degree in Biomedical Engineering.

Elective Requirement

The two elective courses required to fulfill the course requirements for the M.S. and Ph.D. degree are offered within The Henry Samueli School of Engineering and the Schools of Biological Sciences, Physical Sciences, and Medicine. The electives must provide breadth in biomedical engineering, but also provide specific skills necessary to the specific research the student may undertake as part of the degree requirements. The selection of these courses should be based upon approval of the student’s faculty advisor. Upper-division undergraduate courses and courses outside of the HSSoE may be selected upon approval of the BME Graduate Advisor. Elective requirements can be waived for students entering the Ph.D. program with an M.S. degree in Biomedical Engineering.

Areas of Emphasis

Although a student is not required to formally choose a specific research focus area, four research thrust areas have been identified for the program: biophotonics, Biomedical Nanoscale Systems, biomedical computational technologies, and Tissue Engineering. These areas capitalize on existing strengths within The Henry Samueli School of Engineering and UCI as a whole, interact in a synergistic fashion, and will train biomedical engineers who are in demand in both private industry and academia.

Biophotonics. This research area includes the use of light to probe individual cells and tissues and whole organs for diagnostic and therapeutic purposes. The research areas include both fundamental investigation on the basic mechanisms of light interaction with biological systems and the clinical application of light to treat and diagnose disease. Current and future foci of the faculty are (1) microscope-based optical techniques to manipulate and study cells and organelles; (2) development of optically based technologies for the non-invasive diagnosis of cells and tissues using techniques that include fiber-optic-based sensors, delivery systems, and imaging systems; and (3) development of optically based devices for minimally invasive surgery.

Nanoscale Systems. This class of research areas encompasses the understanding, use, or design of systems that are at the micron or submicron level. Current strengths within The Henry Samueli School of Engineering and the UCI faculty as a whole include biomaterials, micro-electromechanical systems (MEMS), and the design of new biomedical molecules. The focus of biomedical engineering research in this area is the integration of nanoscale systems with the needs of clinical medicine. Projected areas of growth include (1) micro-electromechanical systems (MEMS) for biomedical devices and biofluid assay; (2) programmable DNA/ molecular microchip for sequencing and diagnostics; and (3) biomaterials and self-assembled nanostructures for biosensors and drug delivery.

Biomedical Computational Technologies. Biomedical computational technologies include both advanced computational techniques, as well as advanced biomedical database systems and knowledge-base systems. Computational technologies that will be developed in this research area include (1) methods for biomedical analysis and diagnosis such as physical modeling of light-tissue interactions, atomic-level interactions, image processing, pattern recognition, and machine-learning algorithms; (2) language instruction and platform standardization; and (3) machine-patient interfaces. Areas of research related to biomedical database systems include the development of new technologies which can capture the rich semantics of biomedical information for intelligent reasoning.

Tissue Engineering. The term tissue engineering was officially coined at a National Science Foundation workshop in 1988 to mean “the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue function.” Tissue engineering draws on experts from chemical engineering, materials science, surgery, genetics, and related disciplines from engineering and the life sciences. Much of the current research in the field involves growing cells in three-dimensional structures instead of in laboratory dishes. For the most part, cells grown in a flat dish tend to behave as individual cells. But grow a cell culture in a three-dimensional structure, and the cells begin to behave as they would in a tissue or organ. Tissue engineers are testing different methods of growing tissue and organ cells in three-dimensional scaffolds that dissolve once the cells reach a certain mass. The hope is that these cell cultures will mature into fully functional tissues and organs.

Master of Science Degree

Students must successfully complete a minimum of 42 units of course work, as listed under “Core Requirement” and “Elective Requirement” above. A maximum of eight M.S. research units (i.e., BME 296) may be applied toward the 42-unit requirement.

In addition, the M.S. degree requires conducting a focused research project. Students must select a thesis advisor and complete an original research investigation including a written thesis, and obtain approval of the thesis by a thesis committee. During their research project, students are expected to enroll in at least 12 units of independent research per quarter.

The degree will be granted upon the recommendation of the Chair of the Department of Biomedical Engineering and The Henry Samueli School of Engineering Associate Dean for Student Affairs. The maximum time permitted is three years.

NOTE: Students who entered prior to fall of 2012 should follow the course requirements outlined within the Catalogue of the year they entered. The changes in number of units per course is not intended to change the course requirements for the degree nor to have any impact in the number of courses students are taking.

Doctor of Philosophy Degree

The Ph.D. degree requires the achievement of an original and significant body of research that advances the discipline. Students with a B.S. degree may enter the Ph.D. program directly, provided they meet the background requirements described above. The Graduate Committee will handle applicants on a case-by-case basis, and any specific additional courses required by the student will be made explicit at the time of admission.

Each student will match with a faculty advisor, and an individual program of study is designed by the student and their faculty advisor. Two depth courses are required beyond that of the M.S. degree in preparation for the qualifying examination. Six milestones are required: (1) successful completion of 42 units of course work beyond the bachelor’s degree, as listed under “Core Requirement” and “Elective Requirement” above; (2) successful completion of a preliminary examination; (3) establishing an area of specialization by taking two depth courses and three quarters of BME 298 during the second year; (4) formal advancement to candidacy by successfully passing the qualifying examination; (5) students in their third or fourth year must present results of their current research in the BME seminar series; and (6) completion of a significant body of original research and the submission of an acceptable written dissertation and its successful oral defense. During their research project, students are expected to enroll in at least 12 units of independent research per quarter. Students entering the Ph.D. program with an M.S. degree in Biomedical Engineering cannot receive another M.S. degree in Biomedical Engineering from UCI. Therefore, the requirements for milestone (1) can be waived, and the award of the Ph.D. degree is based on achieving milestones (2)–(6).

The preliminary examination will normally be taken at the end of the first year (May). A student must take it within two years of matriculating in the program, and must either have passed all of the core courses or have an M.S. degree in Biomedical Engineering prior to taking the examination. The Preliminary Examination Committee prepares the examination and sets the minimum competency level for continuing on in the Ph.D. program. Students who fail may retake the examination the following year. Students who fail the second attempt will not be allowed to continue in the program. However, they may be eligible to receive a Master’s degree upon completion of an original research investigation including a written thesis (refer to Master of Science Degree requirements). In the event a Ph.D. student decides not to continue in the program, the thesis-only option for the M.S. degree will still be enforced. After passing the preliminary examination at the Ph.D. competency level, students will match with a BME faculty advisor and design an individual program of study with their advisor.

Advancement to candidacy must be completed by the end of the summer of the second year following the passing of the preliminary examination. (Special exceptions can be made, but a formal request with justification must be supplied in writing to the BME Graduate Advisor.) The qualifying examination follows campus and The Henry Samueli School of Engineering guidelines and consists of an oral and written presentation of original work completed thus far, and a coherent plan for completing a body of original research. The qualifying examination is presented to the student’s graduate advisory committee, which is selected by the student and faculty advisor and must have a minimum of five faculty (including the faculty advisor). Of these five faculty, three must be BME faculty. In addition, one faculty member must have his/her primary appointment outside the Department of Biomedical Engineering. The fifth member must have his/her primary appointment outside of The Henry Samueli School of Engineering.

The Ph.D. is awarded upon submission of an acceptable written dissertation and its successful oral defense. The degree is granted upon the recommendation of the graduate advisory committee and the Dean of Graduate Division. The normative time for completion of the Ph.D. is five years (four years for students who entered with a master’s degree). The maximum time permitted is seven years.

Requirements listed here pertain to students enrolled in academic year 2012–13 or later. Students enrolled before this date may refer to a previous version of this Catalogue.

Program in Law and Graduate Studies (J.D./M.S.-BME; J.D./Ph.D.-BME)

Highly qualified students interested in combining the study of law with graduate qualifications in the BME program are invited to undertake concurrent degree study under the auspices of UC Irvine’s Program in Law and Graduate Studies (PLGS). Students in this program pursue a coordinated curriculum leading to a J.D. degree from the School of Law in conjunction with a Master's or Ph.D. degree in the BME program. Additional information is available from the PLGS Program Director’s Office, (949) 824-4158, or by e-mail to plgs@law.uci.edu. A full description of the program, with links to all relevant application information, can be found at http://www.law.uci.edu/plgs and in the Law School section of the Catalogue.

Graduate Program in Mathematical and Computation Biology

The graduate program in Mathematical and Computational Biology (MCB) is a one-year “gateway” program designed to function in concert with selected department programs, including the Ph.D. in Biomedical Engineering. Detailed information is available online at http://mcsb.bio.uci.edu/ and in the School of Biological Sciences section of the Catalogue.

Graduate Specialization in Teaching

The graduate specialization in Teaching will allow Engineering Ph.D. students to receive practical training in pedagogy designed to enhance their knowledge and skill set for future teaching careers. Students will gain knowledge and background in college-level teaching and learning from a variety of sources, and experience in instructional practices. Students completing the specialization in Teaching must fulfill all of their Ph.D. requirements in addition to the specialization requirements. Upon fulfillment of the requirements, students will be provided with a certificate of completion. Upon receipt of the certificate of completion, the students can then append "Specialization in Teaching" to their curricula vitae. For details see http://www.eng.uci.edu/grad/services/specialization.

The graduate specialization in Teaching is available only for certain degree programs and concentrations:

  • Ph.D. degree in Biomedical Engineering
  • Ph.D. degree in Electrical and Computer Engineering
  • Ph.D. degree in Engineering with a concentration in Materials and Manufacturing Technology

Faculty

Michael W. Berns: Photomedicine, laser microscopy, biomedical devices

Elliot Botvinick: Laser microbeams, cellular mechanotransduction, mechanobiology

James P. Brody: Bioinformatics, micro-nanoscale systems

Zhongping Chen: Biomedical optics, optical coherence tomography, bioMEMS, and biomedical devices

Bernard Choi: Biomedical optics, in vivo optical imaging, microvasculature, light-based therapeutics

Steven C. George: Physiological and multi-scale integrative modeling, gas exchange, computational methods, tissue engineering

Enrico Gratton: Design of new fluorescence instruments, protein dynamics, single molecule, fluorescence microscopy, photon migration in tissues

Anna Grosberg: Computational modeling of biological systems, biomechanics, cardiac tissue engineering

Jered Haun: Nanotechnology, molecular engineering, computational simulations, targeted drug delivery, clinical cancer detection

Elliot E. Hui: Microscale tissue engineering, bioMEMS, cell-cell interactions, global health diagnostics

Tibor Juhasz: Laser-tissue interactions; high-precision microsurgery with lasers; laser applications in Ophthalmology; corneal biomechanics

Arash Kheradvar: Cardiac mechanics, cardiovascular devices, cardiac imaging

Michelle Khine: Development of novel nano- and micro-fabrication technologies and systems for single cell analysis, stem cell research, and in-vitro diagnostics

Frithjof Kruggel: Biomedical signal and image processing, anatomical and functional neuroimaging in humans, structure-function relationship in the human brain

Abraham Lee: Lab-on-a-Chip health monitoring instruments, drug delivery micro/nanoparticles, integrated cell sorting microdevices, lipid vesicles as carriers for cells and biomolecules, high throughput droplet bioassays, and microfluidic tactile sensors

Chang C. Liu: Genetic engineering, directed evolution, synthetic biology, chemical biology

Wendy Liu: Biomaterials, microdevices in cardiovascular engineering, cell-cell and cell-micro-environment interactions, cell functions and controls

Zoran Nenadic: Adaptive biomedical signal processing, control algorithms for biomedical devices, brain-machine interfaces, modeling and analysis of biological neural networks

William C. Tang: Microelectromechanical systems (MEMS) nanoscale engineering for biomedical applications, microsystems integration, microimplants, microbiomechanics, microfluidics

Bruce Tromberg: Photon migration, diffuse optical imaging, non-linear optical microscopy, photodynamic therapy

Affiliated Faculty

Mark Bachman: Micro-electro-mechanical systems (MEMS) BIOMEMS, and optoelectronics nonstandard chip processing, physics of small systems

Pierre Baldi: Bioinformatics/computational biology and probabilistic modeling/artificial intelligence and machine learning

Lubomir Bic: Distributed computing, parallel processing in biological systems

Bruce Blumberg: Biorobotics, functional genomics

Peter Burke: Biomedical nanotechnology

Dan M. Cooper: Impact of exercise on exhaled biological gases; novel methods of assessing physical activity in infants and children using biomems; impact of oxygen gradients on neutrophil trafficking

Robert Corn: Surface chemistry, surface spectroscopy, surface biochemistry and biosensing

Carl Cotman: Computational methods in brain aging, Alzheimer’s disease

Nancy A. Da Silva: Molecular biotechnology, metabolic engineering, environmental biotechnology

Hamid Djalilian: Development of devices for hearing loss, dizziness, and ear infections; development of new modalities in the treatment of tinnitus

James Earthman: Biomaterials, dental, and orthopaedic implants

Aaron P. Esser-Kahn: Polymer chemistry, microvascular materials, immune programming

Gregory Evans: Tissue engineering, adult stem cells, embryonic stem cells, nerve regeneration

Lisa Flanagan-Monuki: Stem cells, neural, embryonic, neuron

Ron Frostig: Optical methods for brain imaging, functional organization of the cortex

John P. Fruehauf: In-vitro cancer models using 3-D tissue systems to predict drug response

Steven Gross: In-vivo function of molecular motors, optical tweezers

Zhibin Guan: Chemistry of biomaterials

Gultekin Gulsen: Diffuse optical tomography, fluorescence tomography, MRI, multi-modality imaging

Ranjan Gupta: In-vivo models for chronic nerve injury; in-vitro models for nerve injury

Christopher C. W. Hughes: Tissue engineering, growth and patterning of blood vessels

James V. Jester: Mechanics of wound healing and the inter-relationship of mechanical force, cell-matrix interaction, and gene expression; cellular basis of corneal transparency and the role of water-soluble proteins in isolated cell light scattering; three-dimensional and temporal imaging of cells in intact living tissue

Joyce Keyak: Bone mechanics, finite element modeling, quantitative computed tomography, osteoporosis, tumors, radiation therapy

Baruch D. Kuppermann: Diabetic retinopathy, age-related macular degeneration, the ocular complications of AIDS, drug delivery to the posterior segment of the eye, ocular imaging, retinal cell toxicology

Young Jik Kwon: Gene therapy, drug delivery, cancer-targeted therapeutics, stem cell bioreactors, biomaterials, cell and tissue engineering, mathematical modeling

Jonathan Lakey: Islet transplantation for patients with diabetes, improving methods of islet isolation, characterization and developing novel methods of islet transplantation; biopolymer and encapsulation technologies

Arthur D. Lander: Systems biology of morphogenesis; spatially dynamic models of development, signaling and growth; developmental control

Richard Lathrop: Computational methods in protein engineering

Thay Lee: Orthopaedic biomechanics, investigating the shoulder, knee, and spine focusing on sports, trauma, and total joint replacement

Guann-Pyng Li: Microelectromechanical systems for biomedical applications

Shin Lin: Electronic and optical measurements of physiological and bioenergetic changes associated with mind-body practices and therapies

John S. Lowengrub: Mathematical material science, mathematical fluid dynamics, mathematical biology, computational mathematics, cancer modeling, nanomaterials, quantum dots, complex fluids

Ray Luo: Computational structural biology, mathematical biology, molecular mechanisms of p53 cancer mutants

Marc J. Madou: Fundamental aspects of micro/nano-electro-mechanical systems (MEMS/NEMS), biosensors, nanofluidics, biomimetics

John Middlebrooks: Hearing research, neurophysiology, psychophysics, auditory prosthesis, computational neuroscience, auditory cortex

Sabee Molloi: Medical x-ray imaging physics, application of digital radiography to cardiac imaging, coronary artery flow measurement, digital image processing

J. Stuart Nelson: Phototherapy, dermatology, cell biology, biomedical device development

Hung Duc Nguyen: Thermodynamic computer simulations, nanoscale self-assembly, virus assembly, protein folding/aggregation

Qing Nie: Cell and developmental biology, systems biology and computational biology, and computational mathematics

David Reinkensmeyer: Skeletal muscle control, biorobotics, rehabilitation

Phillip C.-Y. Sheu: Semantic computing, complex biomedical systems

Andrei Shkel: Silicon integrated micro-electro-mechanical sensors and actuators

Ramesh Srinivasan: Perception, development and cortical dynamics

Roger F. Steinert: Lasers for refractive and cataract surgery; artificial lenses and artificial corneas

Vasan Venugopalan: Application of laser radiation for medical diagnostics, therapeutics, and biotechnology; laser-induced thermal, mechanical, and radiative transport processes

Szu-Wen Wang: Biomolecular engineering, nanostructured biomaterials, drug delivery

H. Kumar Wickramasinghe: Nano-bio measurements and technology, ultrafast DNA sequencing, single cell assays, nanoscale delivery and measurements within living cells

Brian Wong: Biomedical optics, tissue engineering, and development of surgical instrumentation

Xiangmin Xu: G-protein signaling; systems biology

Albert Yee: Nanofabrication of soft materials, physics of polymer thin films, nanomechanical properties of polymers, ultra-low-k dielectrics, fracture and toughening of polymer nanocomposites

Fan-Gang Zeng: Cochlear implants and auditory neuroscience 

Weian Zhao: Stem cell therapy, cancer diagnostics

Affiliated faculty are from the Schools of Biological Sciences, Physical Sciences, and Medicine; the Donald Bren School of Information and Computer Sciences; and The Henry Samueli School of Engineering.

Courses

BME 1. Introduction to Biomedical Engineering. 3 Units.

Introduction to the central topics of biomedical engineering. Offers a perspective on bioengineering as a discipline in a seminar format. Principles of problem definition, team design, engineering inventiveness, information access, communication, ethics, and social responsibility are emphasized.

(Design units: 1)

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 50A. Cell and Molecular Engineering. 4 Units.

Physiological function from a cellular, molecular, and biophysical perspective. Applications to bioengineering design.

(Design units: 2)

Corequisite: BME 1.

Restriction: Biomedical Engineering, Chemical Engineering, and Materials Science Engineering majors have first consideration for enrollment.

BME 50B. Cell and Molecular Engineering. 4 Units.

Physiological function from a cellular, molecular, and biophysical perspective. Applications to bioengineering design.

(Design units: 2)

Prerequisite: BME 50A.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 60A. Engineering Analysis/Design: Data Acquisition. 4 Units.

Fundamentals of LabVIEW programming, basics of computer-based experimentation, establishing interface between computer and data acquisition instrumentation, signal conditioning basics.

(Design units: 2)

Corequisite: BME 1.
Prerequisite: Physics 7D.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 60B. Engineering Analysis/Design:Data Analysis. 4 Units.

Overview of MATLAB; numeric, cell, and structurs arrays; file management; plotting and model building; solving linear algebraic equations; differential equations; symbolic process.

(Design units: 1)

Corequisite: MATH 3D.
Prerequisite: BME 60A and MATH 3A.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 60C. Engineering Analysis/Design: Computer-Aided Design. 4 Units.

Introduction to SolidWorks and Computer-Aided Design software; design; analysis; rapid prototyping; visualization and presentation; planning and manufacturing.

(Design units: 2)

Prerequisite: BME 60B.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 110A. Biomechanics I. 4 Units.

Introduction to statics. Rigid bodies, analysis of structures, forces in beams, moments of inertia.

(Design units: 1)

Prerequisite: PHYSICS 7D and PHYSICS 7LD and PHYSICS 7E and BME 50B and BME 60C and MATH 3A and MATH 3D. BME 110A-BME 110B-BME 110C must be taken in the same academic year.

Restriction: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

BME 110B. Biomechanics II. 4 Units.

Introdution to dynamics. Kinematics of Particles, Newton's Second Law, System's of Particles, Kinematics of Rigid Bodies, Motion in three dimensions.

(Design units: 1)

Prerequisite: BME 110A. BME 110A-BME 110B-BME 110C must be taken in the same academic year.

Restriction: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

BME 110C. Biomechanics III. 4 Units.

Applications of statics and dynamics to biomedical systems. Cellular biomechanics, hemodynamics, circulatory system, respiratory system, muscles and movement, skeletal biomechanics. Applications to bioengineering design.

(Design units: 1)

Prerequisite: BME 110B. BME 110A-BME 110B-BME 110C must be taken in the same academic year.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

BME 111. Design of Biomaterials. 4 Units.

Natural and synthetic polymeric materials. Metal and ceramics implant materials. Materials and surface characterization and design. Wound repair, blood clotting, foreign body response, transplanation biology, biocompatibility of material. Artificial organs and medical devices. Government regulations.

(Design units: 3)

Prerequisite: BME 60C. Prerequisite or corequisite: BME 50B.

Restriction: Prerequisite required and Majors only Biomedical Engineering,Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

BME 120. Quantitative Physiology: Sensory Motor Systems. 4 Units.

A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems.

(Design units: 2)

Prerequisite: BME 50B and BME 60C and MATH 3A and MATH 3D.

Restriction: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

Concurrent with BME 220.

BME 121. Quantitative Physiology: Organ Transport Systems. 4 Units.

A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems.

(Design units: 1)

Prerequisite: BME 50B and BME 60C and MATH 3A and MATH 3D.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

Concurrent with BME 221.

BME 130. Biomedical Signals and Systems. 4 Units.

Analysis of analog and digital biomedical signals; Fourier Series expansions; difference and differential equations; convolutions. System models: discrete-time and continuous-time linear time-invariant systems; Laplace and Fourier transforms. Analysis of signals and systems using computer programs.

(Design units: 1)

Prerequisite: BME 60C and MATH 3A and MATH 3D. Recommended: STATS 8.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 135. Photomedicine. 4 Units.

Studies the use of optical and engineering-based systems (laser-based) for diagnosis, treating diseases, manipulation of cells and cell function. Physical, optical, and electro-optical principles are explored regarding molecular, cellular, organ, and organism applications.

(Design units: 0)

Prerequisite: PHYSICS 3C or PHYSICS 7D.

Same as BIO SCI D130.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

BME 136. Engineering Optics for Medical Applications. 4 Units.

Fundamentals of optical system design, integration, and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispersion elements, optical fibers, detectors. Systems integration microscopy, radiometry, interferometry. Optical system analysis: resolution, modulation transfer function, deconvolution, interference, tissue optics, noise.

(Design units: 3)

Prerequisite: BME 130 and BME 135.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

Concurrent with BME 236.

BME 137. Introduction to Biomedical Imaging. 4 Units.

Introduction to imaging modalities widely used in medicine and biology, including X-ray, computed tomography (CT), nuclear medicine (PET and SPET), ultrasonic imaging, magnetic resonance imaging (MRI), optical tomography, imaging contrast, imaging processing, and complementary nature of the imaging modalities.

(Design units: 1)

Prerequisite: BME 130 or EECS 50 or EECS 150.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

BME 138. Spectroscopy and Imaging of Biological Systems. 4 Units.

Principles of spectroscopy; absorption; molecular orbitals; multiphoton transitions; Jablonski diagram; fluorescence anisotropy; fluorescence decay; quenching; FRET; excited state reactions; solvent relaxations; instruments; microscopy: wide field, LSM, TPE; fluorescent probes, fluctuations spectroscopy; optical resolution and super-resolution; CARS and SHG microscopy.

(Design units: 1)

Prerequisite: MATH 3A and MATH 3D. Recommended: STATS 8.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors only.

Concurrent with BME 238.

BME 140. Design of Biomedical Electronics. 4 Units.

Analog and digital circuits in bioinstrumentation. AC and DC circuit analysis, design and construction of filter and amplifiers using operational amplifier, digitization of signal and data acquisition, bioelectrical signal, design and construction of ECG instrument, bioelectrical signal measurement and analysis.

(Design units: 3)

Prerequisite: BME 60C and BME 130.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

BME 147. Microfluidics and Lab-on-a-Chip. 4 Units.

Introduction to principles of microfluidics; LOC (Lab-on-a-Chip) device design, fabrication, operation principles for microscale flow transport, biomolecular manipulation/separation/detection, sample preparation; integrated microfluidic technologies for micro total analysis systems (microTAS) and bioassays. Applications introduced: clinical medicine, health monitoring, biotechnology, biodetection.

(Design units: 1)

Prerequisite: BME 111 and EECS 179.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

Concurrent with BME 247.

BME 148. Microimplants. 4 Units.

Essential concepts of biomedical implants at the micro scale. Design, fabrication, and applications of several microimplantable devices including cochlear, retinal, neural, and muscular implants.

(Design units: 1)

Prerequisite: BME 111 and EECS 179.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

Concurrent with BME 248.

BME 149. Biomedical Microdevices I. 4 Units.

In-depth review of microfabricated devices designed for biological and medical applications. Studies of the design, implementation, manufacturing, and marketing of commercial and research bio-MEMS devices.

(Design units: 0)

Concurrent with BME 249.

BME 150. Biotransport Phenomena. 4 Units.

Fundamentals of heat and mass transfer, similarities in the respective rate equations. Emphasis on practical application of fundamental principles.

(Design units: 1)

Prerequisite: BME 50B and BME 60C and MATH 3A and MATH 3D.

Overlaps with CBEMS 125C.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 160. Tissue Engineering. 4 Units.

Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering design.

(Design units: 2)

Prerequisite: BME 50A and BME 50B and BME 111 and BME 121 and BME 150.

Restriction: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME 170. Biomedical Engineering Laboratory. 4 Units.

Measurement and analysis of biological systems using engineering tools and techniques. Laboratory experiments involve living systems with the emphasis on measuring physiological parameters. Labs: Introduction to Electroenecephalography, Fiberoptic thermometry, Neurorehabilitation Engineering, Spectroscopy principles of the common pulse oximeter. Materials fee.

(Design units: 1)

Prerequisite: BME 111 and BME 120 and BME 121 and BME 130 and BME 140.

Restriction: Biomedical Engineering majors have first consideration for enrollment.

BME 180A. Biomedical Engineering Design. 3 Units.

Design strategies, techniques, tools, and protocols commonly encountered in biomedical engineering; clinical experience at the UCI Medical Center and Beckman Laser Institute; industrial design experience in group projects with local biomedical companies; ethics, economic analysis, and FDA product approval.

(Design units: 3)

Prerequisite: BME 110C and BME 111 and BME 120 and BME 121 and BME 140. BME 180A, BME 180B, and BME 180C must be taken in the same academic year.

Grading Option: In progress only.

Restriction: Seniors only. Biomedical Engineering majors only.

BME 180B. Biomedical Engineering Design. 3 Units.

Design strategies, techniques, tools, and protocols commonly encountered in biomedical engineering; clinical experience at the UCI Medical Center and Beckman Laser Institute; industrial design experience in group projects with local biomedical companies; ethics, economic analysis, and FDA product approval.

(Design units: 3)

Prerequisite: BME 180A. BME 180A, BME 180B, and BME 180C must be taken in the same academic year.

Grading Option: In progress only.

Restriction: Seniors only. Biomedical Engineering majors only.

BME 180C. Biomedical Engineering Design. 3 Units.

Design strategies, techniques, tools, and protocols commonly encountered in biomedical engineering; clinical experience at the UCI Medical Center and Beckman Laser Institute; industrial design experience in group projects with local biomedical companies; ethics, economic analysis, marketing, and FDA product approval.

(Design units: 3)

Prerequisite: BME 180B. BME 180A, BME 180B, and BME 180C must be taken in the same academic year.

Restriction: Seniors only. Biomedical Engineering majors only.

BME 195. Special Topics in Biomedical Engineering. 1-4 Units.

Studies in selected areas of Biomedical Engineering. Topics addressed vary each quarter.

(Design units: 1-4)

Prerequisite: Prerequisites vary.

Repeatability: Unlimited as topics vary.

BME 197. Seminars in Biomedical Engineering. 2 Units.

Presentation of advanced topics and reports of current research efforts in Biomedical Engineering.

(Design units: 1-2)

Restriction: Seniors only. Biomedical Engineering majors have first consideration for enrollment.

Concurrent with BME 298.

BME 199. Individual Study. 1-4 Units.

Independent research conducted in the lab of a biomedical engineering core faculty member. A formal written report of the research conducted is required at the conclusion of the quarter.

(Design units: 1-4)

Prerequisite: BIO SCI 194S.

Repeatability: May be taken for credit for 8 units.

BME 199P. Individual Study. 1-4 Units.

Supervised independent reading, research, or design for undergraduate Engineering majors. Students taking individual study for design credit are to submit a written paper to the instructor and to the Undergraduate Student Affairs Office in the School of Engineering.

(Design units: 1-4)

Grading Option: Pass/no pass only.

Repeatability: May be repeated for credit unlimited times.

BME 210. Cell and Tissue Engineering. 4 Units.

A biochemical, biophysical, and molecular view of cell biology. Topics include the biochemistry and biophysical properties of cells, the extracellular matrix, biological signal transduction, and principles of engineering new tissues.

Restriction: Graduate students only.

BME 213. Systems Cell and Developmental Biology. 4 Units.

Introduces concepts needed to understand cell and developmental biology at the systems level, i.e., how the parts (molecules) work together to create a complex output. Emphasis on using mathematical/computational modeling to expand/modify insights provided by intuition.

Same as DEV BIO 232.

Restriction: Graduate students only.

BME 220. Quantitative Physiology: Sensory Motor Systems. 4 Units.

A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems.

Restriction: Graduate students only.

Concurrent with BME 120.

BME 221. Quantitative Physiology: Organ Transport Systems. 4 Units.

A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems.

Restriction: Graduate only.

Concurrent with BME 121.

BME 230A. Applied Engineering Mathematics I. 4 Units.

Analytical techniques applied to engineering problems in transport phenomena, process dynamics and control, and thermodynamics.

BME 230B. Applied Engineering Mathematics II. 4 Units.

Advanced engineering mathematics for biomedical engineering. Focuses on biomedical system identification. Includes fundamental techniques of model building and testing such as formulation, solution of governing equations (emphasis on basic numerical techniques), sensitivity theory, identifiability theory, and uncertainty analysis.

Restriction: Graduate students only.

BME 233. Dynamic Systems in Biology and Medicine. 4 Units.

Introduces elements of system theory and application of these principles to analyze biomedical, chemical, social, and engineering systems. Students use analytical and computational tools to model and analyze various dynamic systems such as population dynamics, Lotka-Volterra equation, and others.

Restriction: Graduate students only.

BME 234. Neuroimaging Data Analysis. 4 Units.

Recent techniques for the analysis of anatomical and functional neuroimaging data.

Restriction: Graduate students only.

BME 236. Engineering Optics for Medical Applications. 4 Units.

Fundamentals of optical system design, integration, and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispension elements, optical fibers, detectors. Systems integration microscopy, radiometry, interferometry. Optical system analysis: resolution, modulation transfer function, deconvolution, interference, tissue optics, noise.

Prerequisite: BME 130 and BME 135.

Restriction: Graduate students only.

Concurrent with BME 136.

BME 238. Spectroscopy and Imaging of Biological Systems. 4 Units.

Principles of spectroscopy; absorption; molecular orbitals; multiphoton transitions; Jablonski diagram; fluorescence anisotropy; fluorescence decay; quenching; FRET; excited state reactions; solvent relaxations; instruments; microscopy: wide field, LSM, TPE; fluorescent probes, fluctuations spectroscopy; optical resolution and super-resolution; CARS and SHG microscopy.

Prerequisite: MATH 3A and MATH 3D. Recommended: STATS 8.

Restriction: Graduate students only.

Concurrent with BME 138.

BME 240. Introduction to Clinical Medicine for Biomedical Engineering. 4 Units.

An introduction to clinical medicine for graduate students in biomedical engineering. Divided between lectures focused on applications of advanced technology to clinical problems and a series of four rotations through the operating room, ICU, interventional radiology/imaging, and endoscopy.

BME 247. Microfluids and Lab-On-A-Chip. 4 Units.

Introduction to principles of microfluidics; LOC (Lab-on-a-Chip) device design, fabrication, operation principles for microscale flow transport, biomolecular manipulation/separation/detection, sample preparation; integrated microfluidic technologies for micro total analysis systems (microTAS) and bioassays. Applications introduced: clinical medicine, health monitoring, biotechnology, biodetection.

Restriction: Graduate students only.

Concurrent with BME 147.

BME 248. Microimplants. 4 Units.

Essential concepts of biomedical implants at the micro scale. Design, fabrication, and applications of several microimplantable devices including cochlear, retinal, neural, and muscular implants.

Prerequisite: BME 111 and EECS 179.

Concurrent with BME 148.

BME 249. Biomedical Microdevices I. 4 Units.

Indepth review of microfabricated devices designed for biological and medical applications. Studies of the design, implementation, manufacturing, and marketing of commercial and research bio-MEMS devices.

Restriction: Graduate students only.

Concurrent with BME 149.

BME 295. Special Topics in Biomedical Engineering. 1-4 Units.

Studies in selected areas of Biomedical Engineering. Topics addressed vary each quarter.

Prerequisite: Prerequisites vary.

Repeatability: Unlimited as topics vary.

BME 296. Master of Science Thesis Research. 1-16 Units.

Individual research or investigation conducted in the pursuit of preparing and completing the thesis required for the M.S. in Engineering.

Repeatability: May be repeated for credit unlimited times.

Restriction: Graduate students only.

BME 297. Doctor of Philosophy Dissertation Research. 1-16 Units.

Individual research or investigation conducted in the pursuit of preparing and completing the dissertation required for the Ph.D. in Engineering.

Repeatability: May be repeated for credit unlimited times.

BME 298. Seminars in Biomedical Engineering. 2 Units.

Presentation of advanced topics and reports of current research efforts in biomedical engineering. Designed for graduate students in the Biomedical Engineering program.

Grading Option: Satisfactory/unsatisfactory only.

Repeatability: May be repeated for credit unlimited times.

Concurrent with BME 197.

BME 299. Individual Research. 1-16 Units.

Individual research or investigation under the direction of an individual faculty.

Repeatability: May be repeated for credit unlimited times.