2021-22 Edition

Pharmaceutical Sciences (PHRMSCI)

Courses

PHRMSCI 1. New Student Seminar. 1 Unit.

Weekly meetings consisting of presentations by faculty, professional staff, and Peer Academic Advisors provide information about the Pharmaceutical Sciences major, campus resources, learning skills, and special programs and opportunities.

Grading Option: Pass/no pass only.

Restriction: Pharmaceutical Sciences Majors only. New students only.

PHRMSCI 3. Professional Development and Careers in the Pharmaceutical Sciences. 1 Workload Unit.

Designed to help Pharmaceutical Science majors select a career track and prepare for graduate program applications and careers in industry.

Grading Option: Workload Credit Letter Grade with P/NP.

Restriction: Juniors only. Pharmaceutical Sciences Majors only.

PHRMSCI 42. Life 101 . 2 Units.

Covers the latest scientific work on the impact of nutrition, exercise, and lifestyle choices on mental and physical health. Motivates students to make positive changes by fostering personal growth.

PHRMSCI 76. Ethical Conduct of Research. 2 Units.

Covers the ethical responsibilities of biomedical scientists. Topics include, as discussions and case studies, the high standards of science, the responsible conduct of research, animal experimentation, and clinical trials as they relate to the pharmaceutical sciences.

PHRMSCI H80. Drugs and Society. 4 Units.

Where drugs come from, how drugs work, how and why people abuse drugs, the costs of drug abuse on society, which drugs are commonly abused, and how drug abuse can be prevented and treated. Course intended for non-science majors.

Prerequisite: Recommended: High school chemistry and biology.

Restriction: Campuswide Honors Collegium students only.

(II)

PHRMSCI 90. Speaking about Science. 4 Units.

Students learn to effectively prepare and present public speeches and slide presentations. Included are storytelling, informative, commemorative, and persuasive speeches, and scientific presentation. Evaluating speeches and strategies to reduce speaker apprehension is also covered.

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

PHRMSCI 120. Human Physiology. 4 Units.

Covers the function of the human body. All major organ systems are discussed. Designed to prepare students for healthcare careers, such as medicine, pharmacy, dentistry, and for research careers which require basic knowledge of how the human body functions.

Corequisite: PHRMSCI 120L
Prerequisite: BIO SCI 99

Overlaps with BIO SCI E109.

PHRMSCI 120L. Human Physiology Lab. 2 Units.

Designed to complement PHRMSCI 120. Computer-based lab simulations are used to study the function of the human body. Class physically meet for review sessions and exams.

Corequisite: PHRMSCI 120
Prerequisite: BIO SCI E109

Overlaps with BIO SCI E112L.

PHRMSCI 122L. Medical Microbiology Laboratory. 3 Units.

An introduction to the structure, metabolism, cultivation, isolation, classification, and identification of the major groups of bacteria. Additional focus on identification of infection and use of antibiotics in diseased patients.

Prerequisite: BIO SCI 99 and CHEM 51C. CHEM 51C with a grade of C- or better

PHRMSCI 142. Healthspan Sciences. 4 Units.

Covers the complex and multi-factorial process of aging and increases the understanding of factors that contribute to enhanced lifespan, including basic principles of health and wellness and scientifically proven interventions, both pharmacological and non-pharmacological.

Prerequisite: BIO SCI 98 and BIO SCI 99 and PHRMSCI 120

Restriction: Upper-division students only.

PHRMSCI 155. Neuropsychopharmacology. 4 Units.

Mechanisms underlying chemical signaling processes in the nervous system. Fundamental knowledge for understanding the cellular and molecular actions of drugs and their mechanisms of action on synaptic transmission. Applied neuropsychopharmacology including major drug classes and therapeutic uses.

Prerequisite: PHRMSCI 170A. PHRMSCI 170A with a grade of C- or better

Restriction: Upper-division students only.

PHRMSCI 163. Pharmacogenomics and Epigenetics. 4 Units.

Survey of the genetic and epigenetic basis of inter-subject variability in response to drugs. Covers drug efficacy, safety, and need for their optimization in pharmacotherapy. Emphasizes genetic mechanisms of polymorphisms in the pharmacokinetics and pharmacodynamics of representative therapeutic drugs.

Prerequisite: BIO SCI 99

Concurrent with PHRMSCI 263.

PHRMSCI 170A. Molecular Pharmacology I. 4 Units.

Molecular basis of drug-receptor action at the molecular and cellular levels. Structure-function of drug targets emphasizing enzymes, ion channels, and membrane transport proteins. Understanding how the drugs' mechanisms of action contribute to the development of more efficacious and safer drugs.

Prerequisite or corequisite: (CHEM 51C or CHEM H52C) and (PHRMSCI 120 or BIO SCI E109)

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

PHRMSCI 170B. Molecular Pharmacology II. 4 Units.

Introductory survey covering the molecular mechanisms of drugs that target the nervous system, such as anxiolytics, antidepressants, antipsychotics, hypnotics, muscle relaxants, and recreational drugs; drugs related to the immune system, including antibiotics, antihistamines, and immunosuppressants; drugs used to treat cancer.

Prerequisite: PHRMSCI 170A

PHRMSCI 171. Physical Biochemistry. 4 Units.

Thermodynamics and kinetic fundamentals as applied to problems relevant to pharmaceutical sciences such as receptor/enzyme-ligand interactions. Fundamentals of biophysical methods used in the pharmaceutical sciences including structure determination and biomolecular spectroscopy.

Prerequisite: MATH 2B and PHYSICS 3C and (CHEM 1C or CHEM H2C) and BIO SCI 99

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

PHRMSCI 172. Topics in Pharmaceutical Sciences. 2 Units.

Presents information about various fields of research, study, careers, and graduate school opportunities in pharmaceutical sciences. Taught by guest lecturers from various disciplines including 199 research course faculty. Helps Pharmaceutical Sciences students select electives appropriate to their future goals.

Prerequisite or corequisite: BIO SCI 99 and (CHEM 51C or CHEM H52C)

Grading Option: Pass/no pass only.

PHRMSCI 173. Pharmacotherapy. 4 Units.

An exploration of the clinical application of medications to selected disease states. Focus is on an understanding of underlying principles of pharmacology and how this knowledge can be applied to treatment of diseases.

Prerequisite or corequisite: PHRMSCI 170B

PHRMSCI 174. Biopharmaceutics and Nanomedicine. 4 Units.

Introduces theories and tools of new drug formulations. Particularly new novel therapeutics based on biological materials, pathological characteristics utilized to achieve the maximum efficacy and specificity, and drug delivery systems based on emerging nanotechnology are extensively discussed.

Prerequisite: PHRMSCI 170B

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

PHRMSCI 174L. Biopharmaceutics and Nanomedicine Lab. 3 Units.

Introduction to cancer drug screening using cellular models, and confirmation of comprehensive therapeutic efficacy using a live animal model. Includes basic cell culture, cytotoxicity assays, cell analysis, drug circulation test, and tumor eradication and imaging experiments. Materials fee.

Prerequisite: PHRMSCI 170B and BIO SCI 100

(Ib)

PHRMSCI 175. Drug Discovery Computing Techniques. 4 Units.

Techniques used in computer-aided drug discovery, including theory behind these techniques and practical applications. Topics include scientific computing; python; classical force fields and simulations; visualization and movie-making; quantum mechanics in drug discovery; molecular dynamics; solvation models; and several others.

Prerequisite: CSE 41 or I&C SCI 31. CSE 42 or I&C SCI 32 is recommended.

Concurrent with PHRMSCI 275.

PHRMSCI 177. Medicinal Chemistry. 4 Units.

An introduction of the basics of drug activity and mechanisms. Strategies used to identify lead compounds such as natural product chemistry, combinatorial chemistry, molecular modeling, and high-through put screening. Relationship of molecular structure to pharmacological activity.

Prerequisite: CHEM 51A and CHEM 51B and CHEM 51C and (BIO SCI 98 or CHEM 128)

Same as CHEM 177.

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

PHRMSCI 177L. Medicinal Chemistry Laboratory. 3 Units.

An introduction of the basics of drug activity and mechanisms. Strategies used to identify lead compounds such as natural product chemistry, combinatorial chemistry, molecular modeling, and high-through put screening. Relationship of molecular structure to pharmacological activity. Materials fee.

Corequisite: PHRMSCI 177 or CHEM 177.
Prerequisite: CHEM 51A and CHEM 51B and CHEM 51C and BIO SCI 100 and (BIO SCI 98 or CHEM 128)

Same as CHEM 177L.

Restriction: Pharmaceutical Sciences Majors have first consideration for enrollment.

(Ib)

PHRMSCI 179. Emerging Technologies in Pharmaceutical Sciences and Medicine. 4 Units.

Introduces emerging, ground-breaking technologies in pharmaceutical sciences and medicine, including pharmacogenomics, genome editing, and stem cell and engineered T cell therapies. Explores these novel technologies with both their underlying theories and forward-thinking applications.

Concurrent with PHRMSCI 279.

PHRMSCI 197. Professional Internship. 4 Units.

Provides students with opportunity to develop leadership and professional skills necessary for competitive placement in their chosen industry. Students gain new and field-specific skills outside the classroom environment while participating in a supervised internship for a total of 100 hours.

Grading Option: Pass/no pass only.

Repeatability: May be repeated for credit unlimited times.

Restriction: Seniors only.

PHRMSCI 198. Independent Study in Pharmaceutical Sciences. 1-4 Units.

Students interested in independent study should arrange with a faculty member to sponsor and supervise such work. A time commitment of three hours per week per unit is expected. A written report is required at the end of each quarter.

Repeatability: May be taken for credit for 4 units.

PHRMSCI 199. Undergraduate Research. 1-4 Units.

Original research in the laboratory of Pharmaceutical Sciences faculty. Attendance at regular research group meetings is also generally expected, and a quarterly written report is required. Strongly recommended for students considering research careers and/or graduate degree programs.

Repeatability: May be repeated for credit unlimited times.

PHRMSCI H199. Honors Research in Pharmaceutical Sciences. 1-4 Units.

Undergraduate honors research in Pharmaceutical Sciences. A student time commitment of 10-15 hours per week is required.

Repeatability: May be repeated for credit unlimited times.

PHRMSCI 223. Biological Macromolecules. 4 Units.

Introduction to nucleic acid and protein structure, dynamics, and function. Topics include analytical methods, molecular evolution, folding, and catalysis.

Same as CHEM 223.

PHRMSCI 250A. Current Topics in Pharmaceutical Sciences. 1 Unit.

Intended to expose students to the primary literature and current research in the field of Pharmaceutical Sciences. Students analyze and present information for discussion. Guest speakers from academia and industry may participate throughout the quarter.

Grading Option: Satisfactory/unsatisfactory only.

Repeatability: May be taken for credit 3 times.

Restriction: Graduate students only. Math and Computational Biology Majors only.

PHRMSCI 250B. Current Topics in Pharmaceutical Sciences. 1 Unit.

Intended to expose students to the primary literature and current research in the field of Pharmaceutical Sciences. Students analyze and present information for discussion. Guest speakers from academia and industry may participate throughout the quarter.

Prerequisite: PHRMSCI 250A

Grading Option: Satisfactory/unsatisfactory only.

Repeatability: May be taken for credit 3 times.

Restriction: Graduate students only. Math and Computational Biology Majors only.

PHRMSCI 250C. Current Topics in Pharmaceutical Sciences. 1 Unit.

Intended to expose students to the primary literature and current research in the field of Pharmaceutical Sciences. Students analyze and present information for discussion. Guest speakers from academia and industry may participate throughout the quarter.

Prerequisite: PHRMSCI 250B

Grading Option: Satisfactory/unsatisfactory only.

Repeatability: May be taken for credit 3 times.

Restriction: Graduate students only. Math and Computational Biology Majors only.

PHRMSCI 263. Pharmacogenomics and Epigenetics. 4 Units.

Survey of the genetic and epigenetic basis of inter-subject variability in response to drugs. Covers drug efficacy, safety, and the need for their optimization in pharmacotherapy.Emphasizes genetic mechanisms of polymorphisms in the pharmacokinetics and pharmacodynamics of representative therapeutic drugs.

Restriction: Graduate students only.

Concurrent with PHRMSCI 163.

PHRMSCI 264. The RNA World: From Discovery to Mechanism. 4 Units.

Provides a comprehensive understanding of RNA in biology. Use of knowledge gained in organic chemistry, biochemistry, genomics, and molecular biology to understand how RNA is integrated into contemporary biology.

Restriction: Graduate students only.

PHRMSCI 265. New Frontiers in Chemical and Synthetic Biology. 4 Units.

Explores new developments in chemical and synthetic biology that span the areas of chemistry, molecular biology, genetics, bioengineering, systems biology, and computational genomics.

Restriction: Graduate students only.

PHRMSCI 270. Advanced Pharmacology. 4 Units.

Provides a mechanism-based overview of pharmacology with strong emphasis on clinical application of pharmacology. Students learn the most recent advances in pharmacology as they relate to drug discovery, development, and clinical application.

Restriction: Graduate students only.

Concurrent with PHRMSCI 170A.

PHRMSCI 272. Special Topics in Pharmaceutical Sciences. 2-4 Units.

Reserved for current topics of particular interest in areas of pharmaceutical sciences that are not covered by other courses. The subject will vary from year to year, highlighting, for example, significant emerging fields or highly specialized but vital research areas.

Repeatability: Unlimited as topics vary.

Restriction: Graduate students only.

PHRMSCI 275. Drug Discovery Computing Techniques. 4 Units.

Techniques used in computer-aided drug discovery, including theory behind these techniques and practical applications. Topics include scientific computing; python; classical force fields and simulations; visualization and movie-making; quantum mechanics in drug discovery; molecular dynamics; solvation models; and several others.

Restriction: Graduate students only.

Concurrent with PHRMSCI 175.

PHRMSCI 277. Medicinal Chemistry. 4 Units.

Fundamentals of medicinal chemistry covering diverse aspects of drug design, discovery, synthesis, and development. Molecular basis of drug action with an emphasis on the structure-to-function continuum.

PHRMSCI 279. Emerging Technologies in Pharmaceutical Sciences and Medicine. 4 Units.

Introduces emerging, ground-breaking technologies in pharmaceutical sciences and medicine, including pharmacogenomics, genome editing, and stem cell and engineered T cell therapies. Explores these novel technologies with both their underlying theories and forward-thinking applications.

Concurrent with PHRMSCI 179.

PHRMSCI 298. Research Seminar . 2 Units.

Presentation and discussion of current problems and methods in teaching and research in pharmaceutical sciences.

Repeatability: May be repeated for credit unlimited times.

Restriction: Graduate students only.

PHRMSCI 299. Graduate Research. 1-12 Units.

Supervised original research or investigation under the direction of an individual faculty member.

Repeatability: May be repeated for credit unlimited times.

PHRMSCI 399. University Teaching. 1-4 Units.

Limited to Teaching Assistants.

Grading Option: Satisfactory/unsatisfactory only.

Repeatability: May be repeated for credit unlimited times.